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The regulation of cellular metabolism in the diagnosis

Already over 20 years ago, J. Schole published the scientific bases of metabolic regulation in the context of the "three-component theory." The consequences that derive from medicine are very vast because, due to them, it is possible to find a very direct approach to all diseases. Due to the vast topic here, we want to highlight some particularities. Let’s dig into it!

Metabolic regulation

At this point, we refer to the fact that in the "official" opinion concerning metabolic regulation, many inaccuracies appear. One reason is the assumption that depending on a configuration change, the metabolic processes were slowed down and accelerated, a process defined as the Pasteur Effect. But according to today's knowledge, it is revealed that the Pasteur Effect in the front line depends on the oxidation-reduction state of the cell and that it can also become negative. The glutathione system can be considered as a mirror image of the redox system with inter-conversion (switching). Here, direct links to the functional state of the immune system are revealed. The anabolic synthesis and catabolic energy metabolism are linked and influence each other. 

Their activity in the rest state is the same and is guaranteed by the so-called basic regulation characterized by oxidation and reduction processes, by the exchange of electrons (reactions of donors and acceptors of electrons), a constant giving and receiving.

If loads now occur, in the form of stress, but also of toxins, microbes, viruses, etc. - the upper hormonal regulators come into action, to achieve effective adaptation to the load as quickly as possible. During this process, both metabolic parts are not "elevated" simultaneously, but one after the other. The pathological value lies in the delay "in limping behind." In the rested state - with the corresponding reserves of cortisol and anabolic peptides - compensation at a higher energy level takes place within an hour. Otherwise, it takes 4-5 days, accompanied by the symptoms of an acute pathology (which must be understood as a therapeutic reaction) as an "alarm reaction," according to H. Style. According to J. Schole, metabolic regulation can take place if at least three components are active at the same time as so-called "basic regulators." The thyroid hormones and cortisol (they activate the flavin enzymes in the mitochondria, and for this reason, they act at a catabolic level), and ‘STH, and anabolic cell peptides (inhibit flavin enzymes)

Due to the connection with the neurovegetative system, acetylcholine (anabolic) and norepinephrine (catabolic) also play a modulatory role. This is particularly noticeable when we are in the presence of many permanent stressors (outbreaks, toxins, etc.). Further links exist with the sex hormones - estradiol (anabolic) / progesterone (catabolic) and testosterone (anabolic) / corticosteroids (catabolic). The appearance of insufficiencies of the hormonal glands (climacteric of men and women) acts correspondingly. We are also aware that STH, which would be able to bring an excessively catabolic metabolism back to normal (cardio-circulatory diseases, cancer, and others), cannot be issued if the insulin level is too high (due to the abuse of carbohydrates) or in the presence of permanent psychic stress (inhibits the hormone that releases STH).


What has been expressed here at the highest scientific level has far-reaching practical consequences for all medicine, the meaning of which must be considered as revolutionary. Acute diseases arise only if cortisol deposits, or anabolic peptides, are exhausted due to stress, because in this case adaptation under load is no longer possible after the immediate reaction (duration 1 hour). In this case, the "level 2" of the defense program takes place, the alarm reaction, according to Selye, which lasts seven days. Symptoms that occur concurrently (fever, sweating, etc.) must be understood as a therapeutic reaction and must not be suppressed. Chronic diseases are divided - due to their symptomatology - into anabolic and catabolic. 

The cause is, in any case, the failure of polar metabolic activity (energy and synthesis metabolism). The underlying blockage must be diagnosed and treated in a targeted way. This block can be found at all levels of the BEING, starting from the psyche up to a deeply material level. In fact, every chronic disease must be analyzed primarily based on where normal metabolic regulation has been disturbed. Nutrition acts directly on the regulation of metabolism and, thus, on the course of the disease. For this reason, its importance should never be underestimated. The decisive regulatory factor is carbohydrates! Since they are "rapid burners," they essentially stimulate catabolic metabolism, also inhibiting the emission of STH with an anabolic effect. Thus immunosuppression occurs simultaneously. For this reason, carbohydrates should be limited in all catabolic diseases (starting from cardio-circulatory ones up to cancer). Vegetarian nutrition is recommended only in the case of certain anabolic diseases (rheumatism, cirrhosis of the liver, asthma).

Practical application

Each patient with chronic ambulatory problems will first be visited to see if he suffers from an anabolic or catabolic disease, and to what extent his metabolism deviates from the norm. With the ZMR appliance, this is possible on a bioenergetic level in a few minutes. The determination of the "overall metabolic activity" (GAA) is more demanding. There is always the question of what the patient is missing to achieve a normal metabolic situation. All therapeutic approaches must always be analyzed based on their ability to normalize the blocked part. The goal is always to strengthen the weaker part, not to "eliminate" too much. If the problem, e.g., if he were in a perceptual disorder caused by problems of attribution of both cerebral hemispheres, this will have completely different therapeutic consequences, compared to a cause mainly on a psychic or material level.


All chronic diseases can be divided into two groups, one with a metabolic situation blocked by the anabolic part and the other with a metabolic situation blocked from a catabolic point of view (derailment due to a reduced catabolic activity). The goal of therapy must be based on supporting the weaker area, regardless of the level on which the patient is approached. This applies to psychotherapy in the same way as for dietary advice or energy treatments. In this way, empiricism is transformed into causal medicine. Without the knowledge of metabolic regulation, explicitly in his theory of the three components, it is not possible to precisely coordinate the pathophysiological processes in the organism, which can give rise to incorrect interpretations. In the same way, it is impossible to give a correct evaluation of the acid-basic statecellular_metabolism, because this is linked to the quadripolar level with cellular metabolism.


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